The group of over 2,000 people, some from the so-called Plandemic Resistance Movement, slammed official coronavirus-related mandates including vaccinations, tests and masks, responding to new government measures and an inoculation push.
In Turkey's largest such protest, mostly maskless people shouted slogans, held placards and Turkish flags, and sang songs in defense of what they called individual rights, echoing anti-vaccine rallies in some other countries.
Some of the demonstrators were seen wearing gas masks.
"This pandemic is just going on with even more restrictions on our freedoms and there's no end to it," Erdem Boz, a software developer, told Reuters. "Masks, vaccines, PCR tests might all become mandatory. We're here to voice our discontent with this."